Researchers from UCLA and China have discovered that catalase, a naturally occurring enzyme, holds potential as a low-cost therapeutic drug to deal with COVID-19 signs and suppress the replication of coronavirus contained in the physique. A research detailing the analysis was printed in Superior Supplies.
Catalase is produced naturally and utilized by people, animals, and crops. Inside cells, the antioxidant enzyme kick begins the breakdown of hydrogen peroxide, which may be poisonous, into water and oxygen. The enzyme can also be generally used worldwide in meals manufacturing and as a dietary complement.
“There may be a whole lot of deal with vaccines and antiviral medication, and rightly so,” mentioned Yunfeng Lu, a UCLA Samueli Faculty of Engineering professor of chemical and biomolecular engineering and a senior writer on the research. “Within the meantime, our analysis suggests this enzyme may provide a really efficient therapeutic resolution for remedy of hyperinflammation that happens as a consequence of SARS-CoV-2 virus, in addition to hyperinflammation typically.”
Lu’s group developed the drug-delivery know-how used within the experiments. Three kinds of exams have been carried out, every addressing a unique symptom of COVID-19.
First, they demonstrated the enzyme’s anti-inflammatory results and its capacity to control the manufacturing of cytokines, a protein that’s produced in white blood cells. Cytokines are an vital a part of the human immune system, however they will additionally sign the immune system to assault the physique’s personal cells if too many are made — a so-called “cytokine storm” that’s reported in some sufferers identified with COVID-19.
Second, the staff confirmed that catalase can shield alveolar cells, which line the human lungs, from harm as a consequence of oxidation.
Lastly, the experiments confirmed that catalase can repress the replication of SARS-CoV-2 virus in rhesus macaques, a kind of monkey, with out noticeable toxicity.
“This work has far-reaching implications past the remedy of COVID-19. Cytokine storm is a deadly situation that may complicate different infections, similar to influenza, in addition to non-infectious situations, like autoimmune illness,” mentioned Dr. Gregory Fishbein, an writer on the research and a pathologist on the UCLA David Geffen Faculty of Medication.
Reference: “An Antioxidant Enzyme Therapeutic for COVID‐19” by Meng Qin, Zheng Cao, Jing Wen, Qingsong Yu, Chaoyong Liu, Fang Wang, Jianjun Zhang, Fengmei Yang, Yanyan Li, Gregory Fishbein, Sen Yan, Bin Xu, Yi Hou, Zhenbo Ning, Kaili Nie, Ni Jiang, Zhen Liu, Jun Wu, Yanting Yu, Heng Li, Huiwen Zheng, Jing Li, Weihua Jin, Shen Pang, Shuai Wang, Jianfeng Chen, Zhihua Gan, Zhanlong He and Yunfeng Lu, 13 September 2020, Superior Supplies.
The co-lead authors are Zheng Cao, a graduate pupil concerned in Lu’s UCLA laboratory; Jing Wen, an assistant professor of UCLA Faculty of Medication; and Meng Qin from Beijing College of Chemical Know-how.
Along with Fishbein, Bin Xu — a visiting professor with Lu’s laboratory — is one other writer from UCLA.
Researchers on the research are additionally from the Institute of Medical Biology on the Chinese language Academy of Medical Sciences; Jinan College, China; and Vivibaba, a UCLA startup firm.
The research was supported partly by Beijing Science Solar Pharmaceutical Co. Ltd.